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According to research, people with blood type A have a higher positive rate for the SARS-CoV-2 virus, so scientists believe it is necessary to investigate this blood type.
Since the emergence of the new coronavirus, which has severely infected and killed many people, scientists have struggled to study and find answers to the question of whether blood type is related to severity.
New findings by researchers at King's College London are believed to offer potential new ways to treat and prevent the most
severe cases of COVID-19.
To find an answer to this question, researchers at King's College London analysed more than 3,000 proteins to determine if they are associated with the risk of severe COVID-19 disease. This is the first time such a large amount of protein has been examined for a link to COVID-19.
To date, researchers have identified eight proteins that may protect against late-stage COVID-19 and six that may increase the risk of severe COVID-19.
ABO - one of the proteins that increases the risk of severe progression and also determines a person's blood type
Dr. Arish Palmers, co-author of the study, said scientists used pure genetics to study a large number of proteins in the blood and determined that some of them are involved in the risk of severe COVID-19 infection.
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In addition, the scientists identified eight proteins associated with an increased risk of hospitalization, ventilator need, or death, and six proteins that increased those risks. The scientists even distinguished the proteins associated with hospitalization from those associated with patients requiring ventilators.
The scientists therefore concluded that the ABO enzyme that determines blood grouping is associated with an increased risk of hospitalization and use of a ventilator. This reinforces previous findings on the link between blood type and higher risk of death.
People with blood type A have a higher positive rate for SARS-CoV-2 virus
Therefore, scientists believe that it is necessary to investigate this blood type. Study co-author Professor Gerome Breen, Professor of Genetics at King's College London, said the study provided a shortlist for the next phase of research.
Specifically, out of thousands of proteins in blood, the researchers narrowed them down to about 14 proteins associated with the risk of severe COVID-19 infection and outlined important directions for further research. Going further, to better understand the mechanisms of this disease, the ultimate goal is to develop new treatments and preventive measures.
In addition, the researchers identified three "binding" molecules that mediate interactions between immune cells and blood vessels that were associated with a reduced risk of hospitalization. This is consistent with previous research showing that late-stage COVID-19 is a disease involving the lining of blood vessels.
