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Rapid antigen test

Views: 0     Author: Site Editor     Publish Time: 2023-03-03      Origin: Site

Rapid Antigen Test (RAT), sometimes called Rapid Antigen Test (RADT) Rapid Antigen Test (ART), or simply Rapid Test, is a rapid diagnostic test suitable for point-of-care testing that directly detects the presence or Antigen is absent.Such tests are a type of lateral flow test that detects antigens, which distinguishes them from other medical tests that detect antibodies (antibody tests) or nucleic acids (nucleic acid tests), whether they are laboratory types or point-of-care types.Rapid tests typically give results within 5 to 30 minutes, require minimal training or infrastructure, and offer significant cost advantages.Rapid antigen tests for detecting SARS-CoV-2 (the virus that causes COVID-19) have been widely used during the COVID-19 pandemic.Over the years, when referring to RAT or RADT, the early and main class of RAT the rapid strep test for streptococci has been referred to so often that the latter two terms are often treated roughly as synonyms for them.Since the COVID-19 pandemic, awareness of RAT is no longer restricted to health professionals, and COVID-19 has become an expected reference, thus requiring more precise use in other contexts.

RAT is based on the principle of antigen-antibody interaction.Antibodies against the antigen of interest (usually a protein on the surface of the virus) are immobilized on the indicator line of the chromatography substrate and visualized (usually dye-labeled, although sometimes these antibodies are modified to fluoresce).When dissolved sample is added, it moves the visual marker, which then travels with the sample through the chromatography substrate.Viral particles (to which the antibody linked to the visualization marker has bound) are immobilized by the antibody immobilized on the indicator thread as they pass through the matrix. This also immobilizes the bound visual marker, allowing visual detection of significant levels of virus in the sample.Positive results for antigen tests should usually be confirmed by RT-qPCR or other tests with greater sensitivity and specificity.

Rapid antigen test Rapid antigen test

Rapid Antigen Test (RAT), sometimes called Rapid Antigen Test (RADT), Rapid Antigen Test (ART), or simply Rapid Test, is a rapid diagnostic test suitable for point-of-care testing that directly detects the presence or Antigen is absent.Such tests are a type of lateral flow test that detects antigens, which distinguishes them from other medical tests that detect antibodies (antibody tests) or nucleic acids (nucleic acid tests), whether they are laboratory types or point-of-care types.Rapid tests typically give results within 5 to 30 minutes, require minimal training or infrastructure, and offer significant cost advantages.Rapid antigen test for detection of SARS-CoV-2 (the virus that causes COVID-19) has been commonly used during the COVID-19 pandemic.Over the years, when referring to RAT or RADT, the early and main class of RAT the rapid strep test for streptococci has been referred to so often that the latter two terms are often treated roughly as synonyms for them.Since the COVID-19 pandemic, awareness of RAT is no longer restricted to health professionals, and COVID-19 has become an expected reference, thus requiring more precise use in other settings.

RAT is based on the principle of antigen-antibody interaction. Antibodies against the antigen of interest (usually a protein on the surface of the virus) are immobilized on the indicator line of the chromatography substrate and visualized (usually dye-labeled, although sometimes these antibodies are modified to fluoresce).After adding dissolved sample, it mobilizes visual markers, which then travels through the Chromatography substrates and samples.Viral particles (to which the antibody linked to the visualization marker has bound) are immobilized by the antibody immobilized on the indicator thread as they pass through the matrix.This also immobilizes the bound visual marker, allowing visual detection of significant levels of virus in the sample.Positive results of antigen tests should usually be confirmed by RT-qPCR or other tests with higher sensitivity and specificity.

Use

Common examples of RATs or RADTs include:

  • Rapid tests associated with COVID-19 testing

  • Rapid strep test (for strep antigen)

  • Rapid Influenza Diagnostic Test (RIDT) (for influenza virus antigens)

  • Malaria antigen detection test (Plasmodium antigen)

COVID-19 rapid antigen tests

Rapid antigen testing for COVID-19 is one of the most useful applications of these tests.Commonly referred to as lateral flow tests, they offer several benefits to governments around the world.They can be implemented quickly with minimal training, have significant cost advantages at a fraction of the cost of existing PCR assay formats, and provide users with results within 5-30 minutes.Rapid antigen tests have found their best use as part of mass testing or population-wide screening methods.They were successful in these approaches because, in addition to the aforementioned benefits, they identified individuals who were most contagious and likely to spread the virus to a large number of others.This differs slightly from other forms of COVID-19 testing, such as PCR, which are generally seen as useful tests for individuals.As early as February 2021, the U.S. State Department considered that antigen testing was suitable for entry.In Canada, although antigen tests do not appear to be on the market in January 2021 Health Canada subsidized free rapid antigen tests “to more small and medium-sized organizations through new pharmacy partners” in August 2021.